Drs. Lynch and Modarres-Sadeghi were recently awarded an NSF grant titled ‘Mechano-regulation of bone metastatic cancer: linking cell strain to cell function‘ to study how mechanical signals in the skeleton arising from physical activity, which are the primary regulator of bone cell function and remodeling, regulate bone metastatic cancer cells.
Dr. Lynch was recently awarded a UMass Faculty Research Grant/Healey Endowment Grant titled ‘Osteocytes: New Paradigm for Understanding and Treating Bone Metastatic Cancer’ to identify a role for osteocytes, a specialized bone cell, in breast cancer-induced bone disease.
Latest PublicationLatest Publications
Lynch ME, Chiou AE, Lee MJ, Polamraju P, Marcott SC, Lee Y, Fischbach C. “3D mechanical loading modulates the osteogenic response of mesenchymal stem cells to tumor-derived soluble signals.” Tissue Engineering Part A. 22:1006-15, 2016. doi:10.1089/ten.tea.2016.0153
Barney LE, Jansen LE, Polio SR, Galarza S, Lynch ME, Peyton SR. “The predictive link between matrix and metastasis.” Curr Opin Chem Eng. 11:85-93, 2016. doi.org/10.1016/j.coche.2016.01.001
Lynch ME and Fischbach C. “Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations.” Advanced Drug Delivery Reviews, 79-80: 119-34, 2014. doi: 10.1016/j.addr.2014.08.009
The Lynch Lab is looking for energetic Lab members.