Publications

January 27, 2021

Multiphysics simulation of a compression ‐ perfusion combined bioreactor to predict the mechanical microenvironment during bone metastatic breast cancer loading experiments

Liu B, Han S, Modarres-Sadeghi Y, Lynch ME. Multiphysics simulation of a compression – perfusion combined bioreactor to predict the mechanical microenvironment during bone metastatic breast cancer loading experiments. Biotechnol Bioeng. 2021 Jan 25. doi: 10.1002/bit.27692. Epub ahead of print. PMID: 33491767.
December 4, 2019

The Role of Mechanobiology in Cancer

Lynch ME, Neu CP, Seelbinder B, McCreery K (2019). “The Role of Mechanobiology in Cancer.” In Mechanobiological Basis of Diseases. New York, NY: Elsevier. ISBN 9780128179321.
November 9, 2019

Biomechanical Principles

McBride-Gagyi SH and Lynch ME (2019). “Biomechanical Principles.” In Essential Biomechanics for Orthopedic Trauma: A Case Based Guide. ISBN 978-3-030-36989-7.
May 20, 2019

Bone Mechanics in Cancer

Falk CH, Liu B, Lynch ME (2019). “Bone Mechanics in Cancer.” In Encyclopedia of Bone Biology: Cancer and Bone. doi.org/10.1016/B978-0-12-801238-3.11256-5.
December 26, 2018

Perfusion applied to a 3D model of bone metastasis results in uniformly dispersed mechanical stimuli

Liu, B, Han, S, Hedrick, BP, Modarres-Sadeghi, Y, & Lynch, ME (2018). “Perfusion applied to a 3D model of bone metastasis results in uniformly dispersed mechanical stimuli.” Biotechnology and Bioengineering. https://doi.org/10.1002/bit.26524.
July 3, 2018

Mechanically-Loaded Breast Cancer Cells Modify Osteocyte Mechanosensitivity by Secreting Factors That Increase Osteocyte Dendrite Formation and Downstream Resorption

Wang W, Sarazin BA, Kornilowicz G and Lynch ME (2018). “Mechanically-Loaded Breast Cancer Cells Modify Osteocyte Mechanosensitivity by Secreting Factors That Increase Osteocyte Dendrite Formation and Downstream Resorption.” Front. Endocrinol. https://doi.org/10.3389/fendo.2018.00352.
October 3, 2017

Multiscale characterization of the mineral phase at skeletal sites of breast cancer metastasis

He, F, Chiou, AE, Loh, HC, Lynch, ME, Seo, BR, Song, YH, … Fischbach, C. (2017). “Multiscale characterization of the mineral phase at skeletal sites of breast cancer metastasis.” Proceedings of the National Academy of Sciences, 114(40), 10542 LP-10547. https://doi.org/10.1073/pnas.1708161114.
August 1, 2016

3D mechanical loading modulates the osteogenic response of mesenchymal stem cells to tumor-derived soluble signals

Lynch ME, Chiou AE, Lee MJ, Polamraju P, Marcott SC, Lee Y, Fischbach C. “3D mechanical loading modulates the osteogenic response of mesenchymal stem cells to tumor-derived soluble signals.” Tissue Engineering Part A. 22:1006-15, 2016. doi:10.1089/ten.tea.2016.0153.
February 11, 2016

The predictive link between matrix and metastasis

Barney LE, Jansen LE, Polio SR, Galarza S, Lynch ME, Peyton SR. “The predictive link between matrix and metastasis.” Curr Opin Chem Eng. 11:85-93, 2016. doi.org/10.1016/j.coche.2016.01.001.
December 15, 2014

Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations

Lynch ME and Fischbach C. “Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations.”  Advanced Drug Delivery Reviews, 79-80: 119-34, 2014. doi: 10.1016/j.addr.2014.08.009.
May 15, 2014

Load-induced changes in bone stiffness and cancellous and cortical bone mass following tibial compression diminish with age in female mice

Main RP, Lynch ME, van der Meulen MCH. “Load-induced changes in bone stiffness and cancellous and cortical bone mass following tibial compression diminish with age in female mice.” The Journal of Experimental Biology, 217: 1775-83, 2014. doi: 10.1242/jeb.085522.
November 28, 2013

In Vivo Tibial Compression Decreases Osteolysis and Tumor Formation in a Human Breast Cancer Metastasis Model

Lynch ME, Brooks DJ, Mohanan S, Lee MJ, Polamraju P, Dent KC, Bonassar L, van der Meulen MCH, Fischbach C. “In Vivo Tibial Compression Decreases Osteolysis and Tumor Formation in a Human Breast Cancer Metastasis Model.” Journal of Bone and Mineral Research, 28: 2357-2367, 2013. doi: 10.1002/jbmr.1966.
April 29, 2013

Engineered Culture Models for Studies of Tumor-Microenvironment Interactions

Infanger DW, Lynch ME, Fischbach C. “Engineered Culture Models for Studies of Tumor-Microenvironment Interactions.” Annual Review of Biomedical Engineering, 15: 29-53, 2013. doi: 10.1146/annurev-bioeng-071811-150028.
May 27, 2011

Tibial Compression increases Cortical and Cancellous Bone Mass in Adult Female Mice

Lynch ME, Main RP, Xu Q, Schmicker TL, Schaffler MB, Wright TM, van der Meulen MCH. “Tibial Compression increases Cortical and Cancellous Bone Mass in Adult Female Mice.” Bone, 49: 439-46, 2010. doi: 10.1016/j.bone.2011.05.017.
September 10, 2010

Cancellous bone adaptation to tibial compression is not sex-dependent in growing mice

Lynch ME, Main RP, Walsh DJ, Xu Q, Schaffler MB, Wright TM, van der Meulen MCH. “Cancellous bone adaptation to tibial compression is not sex-dependent in growing mice.” Journal of Applied Physiology, 109:685-691, 2010. doi: 10.1152/japplphysiol.00210.2010.
July 31, 2010

In vivo tibial stiffness is maintained by whole bone morphology and cross-sectional geometry in growing female mice

Main RP, Lynch ME, van der Meulen MCH. “In vivo tibial stiffness is maintained by whole bone morphology and cross-sectional geometry in growing female mice.” Journal of Biomechanics, 43:2689-2694, doi: 10.1016/j.jbiomech.2010.06.019.
October 27, 2009

Mesenchymal stem cells and insulin-like growth factor-I gene enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons

Schnabel LV, Lynch ME, van der Meulen MCH, Yeager AC, Kornatowski MA, Nixon AJ. “Mesenchymal stem cells and insulin-like growth factor-I gene enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons.” Journal of Orthopaedic Research, 27: 1392-1398, 2009. doi: 10.1002/jor.20887.