Lynch Lab

October 3, 2017

Multiscale characterization of the mineral phase at skeletal sites of breast cancer metastasis

He, F, Chiou, AE, Loh, HC, Lynch, ME, Seo, BR, Song, YH, … Fischbach, C. (2017). “Multiscale characterization of the mineral phase at skeletal sites of breast cancer metastasis.” Proceedings of the National Academy of Sciences, 114(40), 10542 LP-10547. https://doi.org/10.1073/pnas.1708161114.
August 1, 2016

3D mechanical loading modulates the osteogenic response of mesenchymal stem cells to tumor-derived soluble signals

Lynch ME, Chiou AE, Lee MJ, Polamraju P, Marcott SC, Lee Y, Fischbach C. “3D mechanical loading modulates the osteogenic response of mesenchymal stem cells to tumor-derived soluble signals.” Tissue Engineering Part A. 22:1006-15, 2016. doi:10.1089/ten.tea.2016.0153.
February 11, 2016

The predictive link between matrix and metastasis

Barney LE, Jansen LE, Polio SR, Galarza S, Lynch ME, Peyton SR. “The predictive link between matrix and metastasis.” Curr Opin Chem Eng. 11:85-93, 2016. doi.org/10.1016/j.coche.2016.01.001.
December 15, 2014

Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations

Lynch ME and Fischbach C. “Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations.”  Advanced Drug Delivery Reviews, 79-80: 119-34, 2014. doi: 10.1016/j.addr.2014.08.009.
May 15, 2014

Load-induced changes in bone stiffness and cancellous and cortical bone mass following tibial compression diminish with age in female mice

Main RP, Lynch ME, van der Meulen MCH. “Load-induced changes in bone stiffness and cancellous and cortical bone mass following tibial compression diminish with age in female mice.” The Journal of Experimental Biology, 217: 1775-83, 2014. doi: 10.1242/jeb.085522.
November 28, 2013

In Vivo Tibial Compression Decreases Osteolysis and Tumor Formation in a Human Breast Cancer Metastasis Model

Lynch ME, Brooks DJ, Mohanan S, Lee MJ, Polamraju P, Dent KC, Bonassar L, van der Meulen MCH, Fischbach C. “In Vivo Tibial Compression Decreases Osteolysis and Tumor Formation in a Human Breast Cancer Metastasis Model.” Journal of Bone and Mineral Research, 28: 2357-2367, 2013. doi: 10.1002/jbmr.1966.
April 29, 2013

Engineered Culture Models for Studies of Tumor-Microenvironment Interactions

Infanger DW, Lynch ME, Fischbach C. “Engineered Culture Models for Studies of Tumor-Microenvironment Interactions.” Annual Review of Biomedical Engineering, 15: 29-53, 2013. doi: 10.1146/annurev-bioeng-071811-150028.
May 27, 2011

Tibial Compression increases Cortical and Cancellous Bone Mass in Adult Female Mice

Lynch ME, Main RP, Xu Q, Schmicker TL, Schaffler MB, Wright TM, van der Meulen MCH. “Tibial Compression increases Cortical and Cancellous Bone Mass in Adult Female Mice.” Bone, 49: 439-46, 2010. doi: 10.1016/j.bone.2011.05.017.
September 10, 2010

Cancellous bone adaptation to tibial compression is not sex-dependent in growing mice

Lynch ME, Main RP, Walsh DJ, Xu Q, Schaffler MB, Wright TM, van der Meulen MCH. “Cancellous bone adaptation to tibial compression is not sex-dependent in growing mice.” Journal of Applied Physiology, 109:685-691, 2010. doi: 10.1152/japplphysiol.00210.2010.